Biofabrication of Gelatin Tissue Scaffolds with Uniform Pore Size via Microbubble Assembly

Biofabrication of Tissue Scaffolds

Producing chitin scaffolds with controlled pore size and interconnectivity for tissue engineering

Tissue engineering utilizes cells and synthetic matrices to create new tissues. Living cells are anchorage dependent and will die if they are not provided with an adhesion substrate. Man-made scaffolds are designed to provide a structural framework for the selected cells and to facilitate the formation of new tissues. Matrix structure of the scaffold should be connective together with high poro...

Fabrication of Gelatin Scaffolds Using Thermally Induced Phase Separation Technique

Gelatin is considered as a partially degraded product of collagen and it is a biodegradable polymer which can be used to produce scaffolds for tissue engineering. Three-dimensional, porous gelatin scaffolds were fabricated by thermally induced phase separation and freeze-drying method. Their porous structure and pore size were characterized by scanning electron microscopy. Scaffolds with differ...

Control of pore size and structure of tissue engineering scaffolds produced by supercritical fluid processing.

Tissue engineering scaffolds require a controlled pore size and structure to host tissue formation. Supercritical carbon dioxide (scCO2) processing may be used to form foamed scaffolds in which the escape of CO2 from a plasticized polymer melt generates gas bubbles that shape the developing pores. The process of forming these scaffolds involves a simultaneous change in phase in the CO2 and the ...

The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.

The permeability of scaffolds and other three-dimensional constructs used for tissue engineering applications is important as it controls the diffusion of nutrients in and waste out of the scaffold as well as influencing the pressure fields within the construct. The objective of this study was to characterize the permeability/fluid mobility of collagen-GAG scaffolds as a function of pore size a...